Comparison of different neurite density metrics with brain asymmetry evaluation.

ABSTRACT: The standard diffusion MRI model with intra- and extra-axonal water pools offers a set of microstructural parameters describing brain white matter architecture. However, non-linearities in the standard model and diffusion data contamination by noise and imaging artefacts make estimation of diffusion metrics challenging. In order to develop reliable diffusion approaches and to avoid computational model degeneracy, additional theoretical assumptions allowing stable numerical implementations are required. Advanced diffusion approaches allow for estimation of intra-axonal water fraction (AWF), describing a key structural characteristic of brain tissue. AWF can be interpreted as an indirect measure or proxy of neurite density and has a potential as useful clinical biomarker. Established diffusi

SUBMITTER: Maximov II 

PROVIDER: S-EPMC12166922 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature