The efficacy of immunotherapy combined with capecitabine versus immunotherapy alone as maintenance therapy in patients with de novo metastatic nasopharyngeal carcinoma: a retrospective propensity score matching study.

ABSTRACT:

Background

Chemoimmunotherapy followed by immunotherapy maintenance is recommended as the standard treatment for metastatic nasopharyngeal carcinoma (NPC) patients. While capecitabine maintenance therapy has been shown to improve outcomes in these patients, data on the efficacy of combining capecitabine with immunotherapy maintenance remain limited. This study compared the efficacy of immunotherapy combined with capecitabine maintenance therapy (Immu/Cape) versus immunotherapy maintenance alone (Immu) in patients with de novo metastatic NPC (dmNPC) who received first-line chemoimmunotherapy.

Patients and methods

Patients with dmNPC receiving platinum-based chemoimmunotherapy were included in this study. Propensity score matching (PSM) analysis was employed to balance the bas

SUBMITTER: He SQ 

PROVIDER: S-EPMC12167090 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature