Sestrin2 alleviates cognitive impairment via inhibiting hippocampus ferroptosis in cigarette smoke-induced chronic obstructive pulmonary disease.

ABSTRACT: Cognitive dysfunction is an essential comorbidity that contributing to the whole disease process of the individual of chronic obstructive pulmonary disease (COPD), yet its specific mechanism remains controversial due to a lack of cellular and molecular evidence. Our clinical data revealed a significant reduction in total hippocampal volume in patients with COPD, with the CA1 subfield notably smaller and associated with lung function. Long-term CS exposure caused hippocampus impairment, leading to spatial and working memory impairments in COPD model mice. CS exposure triggered ferroptosis in vivo and in vitro. Bioinformatics analysis suggested that sestrin2 is a key ferroptosis-related gene involved in cognitive impairment. Sestrin2 protein levels were consistently increased in the hippocam

SUBMITTER: Zhang DW 

PROVIDER: S-EPMC12167108 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature