Proteomic signatures of <i>Staphylococcus aureus</i> biofilm maturation on orthopaedic implants.

ABSTRACT: Implant-associated infections pose a significant clinical challenge in the orthopaedic field, often leading to implant failure and revision surgeries. These infections are hard to treat, particularly due to the formation of bacterial biofilms. Orthopaedic implant surfaces feature varying roughness and compositions to optimise implant osseointegration and performance. Highly polished surfaces are used in articulating areas of high shear force to minimise wear particle formation, while rough or porous surfaces enhance implant and bone fixation. However, increased surface roughness or porosity can also promote bacterial adhesion and biofilm formation, potentially elevating the risk of chronic infections. In this study, an automated single-pot solid-phase enhanced sample preparation protocol (

SUBMITTER: Kuik C 

PROVIDER: S-EPMC12167111 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature