The influence of depressive and manic symptoms on suicidal ideation in mixed mood states.

ABSTRACT:

Background

While bipolar disorder is strongly linked to an increased risk of suicide, recent evidence has challenged the assumption that mixed symptoms play a distinct role in suicidal ideation beyond depressive severity. This study examines how depressive, hypo/manic, and mixed features influence suicidal ideation in individuals with bipolar disorder. Data from 903 participants in the Stanley Foundation Bipolar Network (1995-2002) were analyzed to assess associations between mood states, classified by the Inventory of Depressive Symptomatology-Clinician-Rated (IDS-C) and the Young Mania Rating Scale (YMRS), and suicidal ideation, measured using IDS-C item 18, using generalized estimating equations.

Results

Depressive symptoms were strongly associated with suicidal ideation

SUBMITTER: Macellaro M 

PROVIDER: S-EPMC12167198 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature