Evaluation of behavioural and neurochemical effects of psilocybin in mice subjected to chronic unpredictable mild stress.

ABSTRACT: Depression and anxiety are disabling and high incidence mental disorders characterized by phenotypic heterogeneity. Currently available treatments show severe limitations. Thus, there is an urgent need for effective treatments in this population. In the search for novel rapid-acting antidepressants, the psychedelic psilocybin has emerged as a promising therapy in several clinical trials. However, its antidepressant mechanism of action is still not well understood. The aim of the present study was to evaluate the therapeutic potential of psilocybin in ameliorating the adverse behavioural and neurochemical consequences of chronic stress. To this end, a chronic unpredictable mild stress (CUMS) animal model was used, and psilocybin treatment was administered (two doses of 1 mg/kg, i.p., admini

SUBMITTER: Erkizia-Santamaria I 

PROVIDER: S-EPMC12167372 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature