RNA m⁶A methylation patterns in hepatocellular carcinoma and their association with characteristics of the tumor microenvironment and prognosis.

ABSTRACT:

Background

Methylation at the N⁶ atom of adenosine (m⁶A) of RNA has been linked to immune responses to various types of tumors. How m⁶A methylation affects tumorigenicity, progression, and tumor microenvironment in hepatocellular carcinoma (HCC) is unclear.

Methods

Consensus clustering was used to define m⁶A methylation patterns based on expression of 26 regulatory factors in HCC. The relative abundance of various immune cell types in the tumor microenvironment was quantified using single-sample gene set enrichment analysis. Cox regression with LASSO was used to screen for genes whose expression correlated with survival of patients with HCC.

Results

Two patterns of m⁶A methylation in HCC were identified: pattern C

SUBMITTER: Yan Z 

PROVIDER: S-EPMC12167406 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature