Ischemia-free liver transplantation improves long-term outcomes in a 5-year follow-up study.

ABSTRACT:

Background & aims

Ischemia-free liver transplantation (IFLT) is a novel technique designed to avoid ischemia-reperfusion injury (IRI). Here, we report the first detailed 5-year follow-up outcomes.

Methods

We conducted a cohort study comparing long-term outcomes between IFLT and conventional liver transplantation (CLT) recipients of livers donated after brain death (DBD). The primary objective was to evaluate 5-year patient and graft survival. Additional endpoints included graft loss, biliary complications, rejection, infections, and liver-related laboratory tests. Subgroup analysis was performed to validate the generalizability of the results in patients with pre-transplant hepatocellular carcinoma (HCC).

Results

A total of 168 patients were enrolled, with 38 patients

SUBMITTER: Jia Z 

PROVIDER: S-EPMC12167472 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature