DNA stimulates the deacetylase SIRT6 to mono-ADP-ribosylate proteins with histidine repeats.

ABSTRACT: Sirtuins are the NAD⁺-dependent class III lysine deacylases (KDACs). Members of this family have been linked to longevity and a wide array of different diseases, motivating the pursuit of sirtuin modulator compounds. Sirtuin 6 (SIRT6) is a primarily nuclear KDAC that deacetylates histones to facilitate gene repression. In addition to this canonical posttranslational modification "eraser" function, SIRT6 can use NAD⁺ instead to "write" mono-ADP-ribosylation (mARylation) on target proteins. This enzymatic function has been primarily associated with SIRT6's role in the DNA damage response. This modification has been challenging to study because it is not clear under what precise cellular contexts it occurs, only a few substrates are known, and potential interference from

SUBMITTER: Pederson NJ 

PROVIDER: S-EPMC12167490 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature