Identification of CWH43 as a novel prognostic biomarker and therapeutic target in clear cell renal cell carcinoma by a multi-omics approach and correlation with autophagy progression.

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC) poses significant challenges due to its asymptomatic nature and poor prognosis at advanced stages. Identifying novel biomarkers is essential for enhancing prognostic accuracy and therapeutic strategies. This study explores the CWH43 gene, utilizing multi-omics data to determine its role in ccRCC.

Methods

Genomic, transcriptomic, and methylation data from TCGA-KIRC and GEO databases were analyzed to evaluate CWH43 expression and clinical impact. Bioinformatics tools assessed correlations with patient outcomes and pathway involvement.

Results

CWH43 expression was significantly reduced in ccRCC tissues and correlated with advanced disease stages and poor patient survival. Enrichment analyses revealed CWH43's involvement

SUBMITTER: Wu A 

PROVIDER: S-EPMC12167738 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature