Genome-wide association study of urinary cadmium levels in current smokers from the multiethnic cohort study.

ABSTRACT:

Background

Cadmium (Cd), classified as an International Agency for Research on Cancer (IARC) Group 1 human carcinogen, is present in cigarette smoke. Recent studies have illustrated the potential role of genetics in influencing Cd biomarker levels.

Methods

We conducted a genome-wide association study (GWAS) of urinary Cd levels in 1977 current smokers from the Multiethnic Cohort Study, comprising participants from five different racial and ethnic groups. Linear regression models were adjusted for age at urine collection, sex, self-reported race/ethnicity, and the top ten leading principal components.

Results

Among the 11 710 497 single nucleotide polymorphisms (SNP) analyzed, no associations with urinary Cd reached genome-wide significance (P < 5.0 × 10-8). Notably, f

SUBMITTER: Sullivan SM 

PROVIDER: S-EPMC12167763 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature