Melatonin Prevents Tumor Growth: The Role of Genes Controlling the Circadian Clock, the Cell Cycle, and Angiogenesis.

ABSTRACT: Recent evidence highlights the protective role of melatonin in a variety of pathological conditions, including multiple types of cancer. Epidemiological studies increasingly suggest that exposure to light at night suppresses melatonin synthesis in night-shift and rotating-shift workers, potentially elevating their risk of cancer development. Experimental data further indicate that melatonin can inhibit the proliferation of tumor cells, including glioblastoma-like stem cells. In the present study, we investigated the effect of melatonin on the expression of genes involved in regulating the circadian rhythm, cell cycle progression, and angiogenesis in rats exposed to constant light, a model of circadian disruption. Our findings demonstrate that melatonin administration significantly inhibite

SUBMITTER: Cardenas-Romero S 

PROVIDER: S-EPMC12167844 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature