Material properties of biomolecular condensates emerge from nanoscale dynamics.

ABSTRACT: Biomolecular condensates form by phase separation of biological polymers and have important functions in the cell-functions that are inherently linked to their physical properties at different scales. A notable aspect of such membraneless organelles is that their viscoelastic properties can vary by orders of magnitude, but it has remained unclear how these pronounced differences are rooted in the nanoscale dynamics at the molecular level. Here, we investigate a series of condensates formed by complex coacervation of highly charged disordered proteins and polypeptides that span about two orders of magnitude in bulk viscosity. We find that their viscosity is highly correlated with protein translational diffusion and nano- to microsecond chain dynamics. Remarkably, analytical relations from p

SUBMITTER: Galvanetto N 

PROVIDER: S-EPMC12167954 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature