Structure-function coupling in the first month of life: Associations with age and attention.

ABSTRACT: How brain structure relates to function is a critical and open question in neuroscience. Here, we characterize regional variation in structure-function coupling, capturing the degree to which a cortical region's structural connections relate to patterns of coordinated neural activity in healthy, term-born neonates (n = 239). Regional structure-function coupling is heterogeneously patterned across the cortex, with higher coupling in the auditory, lateral prefrontal, and inferior parietal cortices. Average structure-function coupling is negatively associated with age during the first month of life, with age-associated decreases seen in primary sensory systems, specifically in auditory and somatomotor regions. Age-associated "decoupling" of structure and function reflects increasingly

SUBMITTER: Tooley UA 

PROVIDER: S-EPMC12168018 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature