Stereo-EEG propagating source reconstruction identifies new surgical targets for epilepsy patients.

ABSTRACT: Epilepsy surgery can eliminate seizures in patients with drug-resistant focal epilepsy. Surgical intervention requires proper identification of the epileptic network and often involves implanting stereo-EEG electrodes in patients where non-invasive methods are insufficient. However, only ∼60% of patients achieve seizure-freedom following surgery. Quantitative methods have been developed to help improve surgical outcomes. However, previous quantitative methods that localized interictal spike and seizure activity using stereo-EEG recordings did not account for the propagation path encoded by the temporal dynamics of stereo-EEG recordings. Reconstructing the seizure propagation path can aid in determining whether a signal originated from the seizure onset or propagation zone, which directly i

SUBMITTER: Thio BJ 

PROVIDER: S-EPMC12168127 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature