Anoikis classification of lung squamous cell carcinoma reveals correlation with clinical prognosis and immune characteristics.

ABSTRACT:

Background

Anoikis is a new mode of cell death that has been shown to correlate significantly with tumors. However, the clinical prognostic significance of anoikis in lung squamous cell carcinoma (LUSC) remains poorly studied.

Methods

The differentially expressed ARGs and candidate genes were selected by the differential analysis to construct a predictive model. Independent prognostic gene was determined by Cox and LASSO analysis and we used the HCC95 and NCI H520 cell line to verify the gene function. We used the data from TCGA, GEO, GeneCards, and Harmonizome databases to analyze the immune microenvironment, functional enrichment, and drug sensitivity analysis.

Results

We identified 717 differentially expressed and selected 3 ARGs (FADD, SNAI1, and BAG4) to construc

SUBMITTER: Zhai Y 

PROVIDER: S-EPMC12168404 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature