Association of supragingival plaque management with subgingival microbiota is moderated by adjunctive antibiotics in stage III-IV periodontitis patients during periodontal therapy.

ABSTRACT:

Background

This study examines the relationship between supragingival plaque control and subgingival microbiota during periodontal therapy, focusing on microbial clusters associated with plaque levels.

Methods

Data were drawn from a 26-month multicenter, double-blinded, randomized, placebo-controlled trial. Supragingival plaque was measured using the O'Leary index, and subgingival microbiota were profiled via Illumina 16S rRNA gene sequencing. A novel topic modelling approach using cross-validated Latent Dirichlet Allocation (LDA) identified microbial clusters, and negative binomial mixed models evaluated their association with plaque levels.

Results

Supragingival plaque was positively associated with bleeding on probing (BOP) and microbial diversity, but not with dys

SUBMITTER: Saberi Kakhki KCL 

PROVIDER: S-EPMC12168411 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature