Posttraumatic hyperalgesia and associated peripheral sensitization after temporomandibular joint injury in mice.

ABSTRACT:

Abstract

Temporomandibular disorder (TMD) is the most prevalent painful condition in the craniofacial area. Recent studies have suggested that external or intrinsic trauma to the temporomandibular joint (TMJ) is associated with the onset of painful TMD in patients. Here, we investigated the effects of TMJ trauma through forced-mouth opening (FMO) in mice to determine pain behaviors and peripheral sensitization of trigeminal nociceptors in both sexes. Forced-mouth opening increased mechanical pain as assessed by the von Frey test, with spontaneous pain-like behaviors assessed using the mouse grimace scale and anxiety-like behaviors assessed using the open-field test. Changes in pain-like behaviors were not different between male and female mice. However, in vivo GCaMP Ca 2+ imaging

SUBMITTER: Alshanqiti I 

PROVIDER: S-EPMC12168817 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature