Systematic review of oxygenation and clinical outcomes to inform oxygen targets in critically ill trauma patients.

ABSTRACT:

Background

Oxygen therapy is frequently administered to critically ill trauma patients to avoid hypoxia, but optimal oxygenation strategies are not clear.

Methods

We conducted a systematic review of oxygen targets and clinical outcomes in trauma and critically ill patients. We searched Ovid MEDLINE, Cochrane Library, Embase, and Web of Science Core Collection from 1946 through 2017. Our initial search yielded 14,774 articles with 209 remaining after abstract review. We reviewed full text articles of human subjects with conditions of interest, an oxygen exposure or measurement, and clinical outcomes, narrowing the review to 43 articles. We assessed article quality using Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) criteria.

Results

Of the

SUBMITTER: Douin DJ 

PROVIDER: S-EPMC12169140 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature