Evaluation of antiseizure medication concentration ranges in blood samples using an automated big data approach.

ABSTRACT:

Objective

The aim of the study is to provide insight into the real-world use of therapeutic drug monitoring (TDM) for the most common antiseizure medications (ASMs).

Methods

In total, 137 586 samples from the period 2019-2023 were collected from the five main Danish laboratories performing TDM. A previously described algorithm developed to exclude abnormal TDM results from patient data was applied. This resulted in the inclusion of 84 951 samples from 53 406 patients. Concentration ranges were calculated as 10th to 90th percentiles for the datasets of the ASMs: brivaracetam, carbamazepine, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, perampanel, phenobarbital, topiramate, valproic acid, and zonisamide. The observed concentration ranges were compared to the establis

SUBMITTER: Nersesjan M 

PROVIDER: S-EPMC12169409 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature