A Comprehensive Target Panel Allows to Extend the Genetic Spectrum of Neuroendocrine Tumors.

ABSTRACT:

Introduction

Neuroendocrine tumors (NETs) frequently have a genetic basis, and the range of genes implicated in NET development continues to expand. Application of targeted gene panels (TGPs) in next-generation sequencing is a central strategy for elucidating novel variants associated with NET development.

Methods

In this study, we conducted comprehensive molecular genetic analyses using TGP on a cohort of 93 patients diagnosed with various NETs subtypes, mainly accompanied by various endocrine syndromes: insulinoma (n = 26), pheochromocytoma and paraganglioma (PPGL) (n = 38), parathyroid adenoma (n = 18, including three with insulinoma), and NETs of other locations (n = 14). The TGP encompassed genes linked to diverse NETs and other hereditary endocrine disorders, with subs

SUBMITTER: Tsoy UA 

PROVIDER: S-EPMC12169807 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature