Detection of Felis catus papillomavirus-derived genes in squamous cell carcinoma tissues in cats in Japan.

ABSTRACT: Felis catus papillomavirus (FcaPV) was first discovered in 2002. Seven genotypes (FcaPV-1/-2/-3/-4/-5/-6/-7) have been reported to date, at least one of which (FcaPV-2) is suggested to be implicated in squamous cell carcinoma (SCC); however, relevant epidemiological data on Japanese cats are limited. There is one report on relatively low FcaPV-2 prevalence in cats with SCC, largely in the Tokyo region. In this study, we investigated the prevalence of each FcaPV genotype in cats with SCC largely drawn from a peripheral region of Japan (Kyushu). Formalin-fixed paraffin-embedded (FFPE) specimens from 107 cats with SCC were subjected to DNA extraction for type-specific PCR assays, followed by confirmatory nucleotide sequencing. Overall, 16 cases (15.0%) were positive for FcaPV, and the results

SUBMITTER: Uchimura Y 

PROVIDER: S-EPMC12169896 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature