Risk factors for the development of <i>Clostridioides difficile</i> infection in patients colonized with toxigenic <i>Clostridioides difficile</i>.

ABSTRACT:

Objective

Asymptomatic patients colonized with toxigenic Clostridioides difficile are at risk of progressing to C. difficile infection (CDI), but risk factors associated with progression are poorly understood. The objectives of this study were to estimate the incidence and identify risk factors to progression of hospital-onset CDI (HO-CDI) among colonized patients.

Methods

This was a nested case-control study at an academic medical center including adult patients colonized with toxigenic C. difficile, detected via polymerase chain reaction (PCR) on a rectal swab collected on admission from 2017 to 2020. Patients with prior CDI or symptoms on admission, neutropenia, prior rectal surgery, or hospitalization less than 24 hours were excluded. Colonized patie

SUBMITTER: Clement J 

PROVIDER: S-EPMC12169943 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature