Development of a prognostic model for overall survival in neuroblastoma based on Schwann cell-specific genes, clinical predictors, and MYCN amplification.

ABSTRACT:

Background

Neuroblastoma (NBL) is a common pediatric malignancy with diverse prognoses influenced by multiple factors. Accurate overall survival (OS) predictions are essential for guiding treatment. However, the contribution of specific cell types within the tumor microenvironment (TME), which significantly influence disease progression, is often overlooked. This study aimed to develop an NBL prognostic model that incorporates TME, genetic, and clinical factors to improve prediction accuracy and clinical relevance.

Methods

Data were collected from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database (n=106, test set) and the Gene Expression Omnibus (GEO) database (n=238, train set). Including clinical details such as MYCN amplification,

SUBMITTER: Li Z 

PROVIDER: S-EPMC12170041 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature