Prognostic role of tumor microenvironment and immune- and autophagy-related genes in colorectal adenocarcinoma.

ABSTRACT:

Background

Colorectal adenocarcinoma (COADREAD) is the second most common cause of cancer-associated deaths. Immunity and autophagy play a key role in the development and progression of COADREAD, but the specific mechanisms have not been fully elucidated. We aimed to explore immune- and autophagy-related genes (IARGs) to establish prognostic risk assessment and clinical prediction models and to understand the molecular basis of COADREAD.

Methods

Transcriptomic and clinical data from colon (COAD) and rectal cancers (READ) were obtained from TCGA and GEO databases, including 460 COADREAD cases and validation cohorts (GSE161158/GSE17536). Immune-related (IRGs) and autophagy-related genes (ARGs) were integrated to identify 22 immune-autophagy-related genes (IARGs). Molecular sub

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12170119 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature