The lncRNA MIR22HG suppresses prostate cancer cell proliferation, migration, and epithelial-mesenchymal transition via the miR-4428/PCDH9 axis.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) play crucial roles in modulating the development and progression of human malignant cancers. As a tumour suppressor gene, the lncRNA MIR22HG has been identified in many kinds of cancers. However, the specific function of MIR22HG in prostate cancer (Pca) has yet to be elucidated. Specifically, we sought to determine whether MIR22HG plays a role in Pca progression and the underlying mechanisms involved.

Methods

Differentially expressed lncRNAs in Pca tissues were screened by sequencing, and the expression of MIR22HG in cells and tissues was determined via quantitative real-time polymerase chain reaction (qRT-PCR). Cell Counting Kit-8 (CCK8), Transwell, and western blotting assays were used to determine whether Pca cell proliferation an

SUBMITTER: Li A 

PROVIDER: S-EPMC12170257 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature