Construction of a prognostic model for lung adenocarcinoma based on necroptosis genes and its exploration of the potential for tumor immunotherapy.

ABSTRACT:

Background

Lung cancer ranks among the most prevalent malignancies globally, with lung adenocarcinoma (LUAD) being its most frequent histological subtype. Necroptosis is a newly defined mode of programmed cell death that is different from apoptosis and necrosis. However, the role of necroptosis in the occurrence and development of LUAD remains largely unexplored. This study aimed to construct a prognostic model of LUAD based on necroptosis-related genes (NRGs) and analyze the predictive value of this model on the prognosis of LUAD patients.

Methods

The dataset of LUAD patients was downloaded from The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) database, and the NRGs were downloaded from inside GeneCards and Harmonizome databases. LUAD prognostic mod

SUBMITTER: Liu X 

PROVIDER: S-EPMC12170285 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature