Low-dose interleukin-2 induces clonal expansion of BACH2-repressed effector regulatory T cells following acute coronary syndrome.

ABSTRACT: Targeting inflammation in atherosclerotic cardiovascular disease remains a major unmet need. Low-dose interleukin-2 (IL-2_LD) selectively increases regulatory T (T_reg) cell numbers in patients with coronary artery disease. Here we combine single-cell transcriptomics and T cell receptor analyses and show that IL-2_LD clonally expands effector T_reg cells in patients with acute coronary syndromes. The clonally expanded T_reg cells upregulate key immunosuppressive and metabolic pathways and show an increased number of predicted ligand-receptor interactions. These T_reg cells also display similar predicted antigen specificities, which cluster with published sequences specific to atherosclerotic cardiovascular disease. By tracking the

SUBMITTER: Case AG 

PROVIDER: S-EPMC12170346 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature