Retinoic acid metabolism related gene CYP26B1 promotes tumor stemness and tumor microenvironment remodeling in bladder cancer.

ABSTRACT: Background: The previous studies have shown that the retinoic acid (RA) metabolism is closely related to the cancer stemness, but its role in bladder cancer development has not been fully investigated. Methods: We conducted a comprehensive analysis of mutations, copy number variations and transcriptional changes of RA metabolism related genes in bladder cancer cells. We evaluated the activity of RA metabolism in tumor cells by using single cell transcriptome data and identified differentially expressed genes (DEGs) in cell subsets with high RA-metabolism score. We also investigated and verified the biological function of CYP26B1 (one of RA metabolism related genes) in vitro. Additionally, we analyzed and verified the relationship between CYP26B1 and tumor

SUBMITTER: Gu J 

PROVIDER: S-EPMC12170498 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature