A Comprehensive Analysis of the Role of DSN1 in Pan-Cancer Prognosis and Immunotherapy.

ABSTRACT: Background: Dosage Suppressor of NNF1 (DSN1) is a component of the MIS12 kinetochore complex crucial in the cell cycle process. Recent evidence indicates its close association with cancer progression. The study aims to further explore DSN1's role in cancer. Methods: Using public databases, we investigated the expression patterns of DSN1 in mRNA, protein, and single-cell sequencing data across cancer types. Prognostic associations were assessed through survival analysis, and gene mutation frequencies were compared between high and low DSN1 expression groups. Gene set enrichment analysis was conducted to identify relevant biological pathways. We also examined the correlation of DSN1 with DNA methylation, tumor mutation burden (TMB), microsatellite instability (MSI), immune infi

SUBMITTER: Xu D 

PROVIDER: S-EPMC12170500 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature