Advanced imaging characterization of post-chemoradiation glioblastoma stratified by diffusion MRI phenotypes known to predict favorable anti-VEGF response.

ABSTRACT:

Purpose

Recurrent glioblastomas showing a survival benefit from anti-VEGF agents are known to exhibit a distinct diffusion MRI phenotype. We aim to characterize advanced imaging features of this glioblastoma subset.

Methods

MRI scans from 87 patients with IDH-wildtype glioblastoma were analyzed. All patients had completed standard chemoradiation and were anti-VEGF-naïve. Contrast-enhancing tumor segmentations were used to extract: the lowest peak of the double gaussian distribution of apparent diffusion coefficient values (ADC_L) calculated from diffusion MRI, relative cerebral blood flow (rCBV) values from perfusion MRI, MTR_asym @ 3ppm from pH-weighted amine CEST MRI, quantitative T₂ and T₂* relaxation times (qT₂ and qT<

SUBMITTER: Sanvito F 

PROVIDER: S-EPMC12170782 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature