Effects of methamphetamine on two measures of reward: Euphoria and neural activation to reward cues.

ABSTRACT: Stimulants enhance dopamine function, affecting diverse aspects of reward function from neural processing of reward cues to feelings of well-being in humans. However, little is known about the relationships among different measures of reward function. Understanding relationships among different indices of reward processing could provide insight into the processes that control motivated behavior. The present study examined the effects of a single dose of methamphetamine on two measures of reward in healthy adults: feelings of well-being and neural activation with reward-related stimuli. In a randomized, within-subject, double-blind study, 88 healthy men and women received a single 20 mg oral dose of methamphetamine (MA) and placebo, across two sessions. Regional activations to reward-relate

SUBMITTER: Molla H 

PROVIDER: S-EPMC12170867 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature