Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice.

ABSTRACT: Attention-deficit hyperactivity disorder (ADHD) is a prevalent psychiatric disorder with high heritability, while its etiology and pathophysiology remain unclear. Med23 is a subunit of the Mediator complex, a key regulator of gene expression by linking transcription factors to RNA polymerase II. The mutations of Med23 are associated with several brain diseases including microcephaly, epilepsy and intellectual disability, but its biological roles in brain development and possible behavioral consequence have not been explored in the animal model. In this study, Emx1-Cre mice were used to generate Med23 conditional knockout (Med23 CKO) mice that showed severe hypoplasia of the dentate gyrus (DG) with malformation of the dendritic tree and spines along with impaired short-term synaptic plastic

SUBMITTER: Zhou BY 

PROVIDER: S-EPMC12170885 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature