Autoantibodies cause nociceptive sensitization in a mouse model of degenerative osteoarthritis.

ABSTRACT:

Abstract

Previous preclinical and translational studies suggest that tissue trauma related to bony fracture and intervertebral disk disruption initiates the formation of pronociceptive antibodies that support chronic musculoskeletal pain conditions. This study tested this hypothesis in the monosodium iodoacetate (MIA) mouse model of osteoarthritis (OA) and extended the findings using OA patient samples. Monosodium iodoacetate was injected unilaterally into the knees of male and female wild-type (WT) and muMT mice (lacking B cells) to induce articular cartilage damage. Repeated nociceptive behavioral testing was performed, and serum was collected for antibody isolation and passive transfer experiments. Serum antibodies collected from patients with OA were tested in MIA-treated muMT

SUBMITTER: Guo TZ 

PROVIDER: S-EPMC12170920 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature