Gonadotropins differentially regulate testicular cell adhesion and junctional complexes during flatfish spermiogenesis through the oxytocin and relaxin signaling pathways.

ABSTRACT:

Introduction

The molecular mechanisms regulating teleost semicystic spermatogenesis remain largely unknown. In the flatfish Senegalese sole (Solea senegalensis), haploid round spermatids released into the lumen of the seminiferous tubules resume spermiogenesis (the differentiation of germ cells into spermatozoa) in response to the luteinizing hormone (Lh). However, how the spermatids detach from Sertoli cells and how Lh crosses the blood-testis barrier (BTB) are yet to be determined.

Methods

Here, we used an RNA-seq transcriptomic analysis of the testis from sole males treated with recombinant follicle stimulating hormone and Lh (rFsh and rLh, respectively).

Results

This analysis reveals that both gonadotropins differentially downregulate a number of transcript

SUBMITTER: Lopez-Fortun N 

PROVIDER: S-EPMC12171224 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature