Salbutamol for analgesia in renal colic: a prospective, randomised, placebo-controlled phase II trial.

ABSTRACT:

Background

The pain of renal colic, mediated in part by ureteral spasm and inflammation, is often severe and difficult to control. Salbutamol has been shown to cause ureteral relaxation, but its effects on the pain of renal colic have never been studied. The objective of this trial was to investigate whether the use of intravenous salbutamol in addition to standard analgesia was associated with greater pain reduction compared with standard analgesia alone in patients presenting to emergency departments (EDs) with renal colic.

Methods

This single-centre, double-blind, phase II, randomised, placebo-controlled trial recruited adult (≥18 years) ED patients with clinically suspected renal colic. Participants were randomised in a 1:1 ratio to receive either 250 µg of intravenous s

SUBMITTER: Johnson GD 

PROVIDER: S-EPMC12171521 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature