Gut Mucosal Microbiome of Patients With Low-Grade Adenomatous Bowel Polyps.

ABSTRACT:

Background and aims

Colorectal cancer etiology is multifactorial and influenced by colonic environmental exposures leading to the accumulation of genetic lesions in precancerous polyps. There is growing recognition for a role of the gut microbiome in colorectal cancer progression, but the structure of the gut mucosal microbiome in the early stages of polyp growth is limited. The aim of this study was to characterize the gut mucosal microbiome from patients with low-grade conventional bowel neoplasia compared to symptomatic but polyp-free patients.

Methods

In this case-control study conducted at a tertiary referral hospital, 148 symptomatic patients undergoing colonoscopy were prospectively recruited. Mucosal biopsies adjacent to low-grade dysplasia (LGD) adenomatous polyps w

SUBMITTER: Welham Z 

PROVIDER: S-EPMC12171549 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature