Phenyltriazole-based sulfonamides: novel dual-target agents against MRSA biofilms and resistant pathogens.

ABSTRACT: The advent of multidrug-resistant bacteria requires the continuous development of new antimicrobial agents. A series of phenyltriazole-sulfonamide hybrid compounds (16-27) have been synthesized and evaluated for their antimicrobial properties, with a focus on combating resistant bacterial strains such as methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii AB5075. Compounds were synthesized through a multi-step reaction, including alkylation and aminoguanidine substitution, with structural elucidation performed using NMR and elemental analysis. Antimicrobial activity was assessed through Minimum Inhibitory Concentration (MIC) measurements, which revealed that compounds with longer alkyl chains or specific functional groups had a very enhanced activit

SUBMITTER: Hussien A 

PROVIDER: S-EPMC12171725 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature