Biological and Phytochemical Insights Into <i>Opuntia ficus-indica</i> (L.) Mill: Cytotoxic, Wound-Healing, and Anti-Aging Potentials.

ABSTRACT: Opuntia ficus-indica (L.) Mill. has cultivated wild forms in many parts of the world, attracting notably with its fruit. Its fruits can be eaten raw or processed. Studies have shown that fruit juice has various pharmacological effects and significant nutritional value. This study investigated the phenolic composition of O. ficus-indica fruit juice. Caffeic acid was the major component. Cytotoxic activity and wound-healing effect were evaluated by in vitro assays. Results showed a concentration-dependent response, with the lowest viability (111.89% ± 17.90%) at 1000 μg/mL and the highest (162.25% ± 7.48%) at 250 μg/mL. The extract (0-250 μg/mL) had comparable wound closure to the control group. It increased the lifespan of Caenorhabditis elegans, an

SUBMITTER: Kendir G 

PROVIDER: S-EPMC12171788 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature