Real-world data on immune checkpoint inhibitors in advanced sarcomas across multiple European institutions.

ABSTRACT:

Background

Following the success of immune checkpoint inhibitors (ICI) in other cancer types, their role is being evaluated in sarcomas. They have been assessed as monotherapy, or in combination with other ICI, chemotherapeutic drugs and tyrosine kinase inhibitors (TKI) in several clinical trials. So far the results have been limited to non-selected sarcoma populations. Further work is required to select patients who will benefit from immunotherapy.

Patients and methods

We conducted a pooled retrospective analysis of the use of ICI in patients with advanced sarcomas in multiple European institutions. ICI-based treatments included ICI monotherapy (n = 43, 59.7%), double ICI (n = 5, 6.9%), ICI plus TKI (n = 21, 29.2%) and ICI plus chemotherapy (n = 3, 4.2%).

Results

Sev

SUBMITTER: Kokkali S 

PROVIDER: S-EPMC12171866 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature