Stretchable electrode enabled electrochemical mass spectrometry for <i>in situ</i> and complementary analysis of cellular mechanotransduction.

ABSTRACT: Mechanotransduction exerts a profound influence on diverse cellular processes via activated signalling pathways. Although the currently established methods could reveal force-induced ultimate changes in specific biochemical cues, they fail to provide real-time and comprehensive information about the complicated signaling events. Herein, we report stretchable electrode enabled electrochemical mass spectrometry for in situ and complementary analysis of cellular mechanotransduction. The stretchable electrode functions as not only an electrochemical sensor for tracking the electroactive molecules released from stretched cells cultured thereon, but also an ionization source to ionize the intracellular metabolites for mass spectrometry analysis. As a concept application, the endoth

SUBMITTER: Wang H 

PROVIDER: S-EPMC12171969 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature