Multi-omics surveillance of antimicrobial resistance in the pig gut microbiome.

ABSTRACT:

Background

High-throughput sequencing technologies play an increasingly active role in the surveillance of major global health challenges, such as the emergence of antimicrobial resistance. The post-weaning period is of critical importance for the swine industry and antimicrobials are still required when infection occurs during this period. Here, two sequencing approaches, shotgun metagenomics and metatranscriptomics, have been applied to decipher the effect of different treatments used in post-weaning diarrhea on the transcriptome and resistome of pig gut microbiome. With this objective, a metagenome-assembled genome (MAG) catalogue was generated to use as a reference database for transcript mapping obtained from a total of 140 pig fecal samples in a cross-sectional and longitudin

SUBMITTER: Guitart-Matas J 

PROVIDER: S-EPMC12172226 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature