Fecal microbiota transplantation from patients into animals to establish human microbiota-associated animal models: a scoping review.

ABSTRACT:

Background

Fecal microbiota transplantation (FMT) from humans with specific medical conditions to animal models can demonstrate causality by inducing or exacerbating pathophenotypes, linking the gut microbiota to health outcomes.

Methods

We conducted a scoping review searching MEDLINE, EMBASE, Scopus, and Web of Science through July 2024 to identify human noninfectious diseases studied using FMT in animal models, investigate FMT methodologies, and assess the feasibility of systematic reviews on the role of the microbiota in specific diseases.

Results

From 605 reports of 489 studies, we found that inflammatory bowel diseases, irritable bowel syndrome, obesity, colorectal cancer, and depression were the most commonly studied, with cancer research focusing on immunothera

SUBMITTER: Ruszkowski J 

PROVIDER: S-EPMC12172294 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature