Independent validation and outlier analysis of EuroPOND alzheimer's disease staging model using ADNI and real-world clinical data.

ABSTRACT:

Background

Event-based modeling (EBM) traces sequential progression of events in complex processes like neurodegenerative diseases, adept at handling uncertainties. This study validated an EBM for Alzheimer's disease (AD) staging designed by EuroPOND, an EU-funded Horizon 2020 project, using research and real-world datasets, a crucial step towards application in multi-center trials.

Methods

The training dataset comprised 1737 subjects from ADNI-1/GO/2, using the EuroPOND EBM toolbox. Testing datasets included a research cohort from University of Antwerp (controls, CN (n = 46), subjective cognitive decline, SCD (n = 10), mild cognitive impairment, MCI (n = 47), AD dementia, ADD (n = 16)) and a real-world cohort from 9 Belgian Dementia Council memory clinics (CN (n = 91), SCD

SUBMITTER: Wittens MMJ 

PROVIDER: S-EPMC12172318 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature