Extensive Clinical Flow Cytometric Lymphocyte Phenotyping in Myasthenia Gravis: A Single-Center Study.

ABSTRACT: Myasthenia gravis (MG) is an autoimmune neurological disease characterized by potentially life-threatening muscular fatiguability. Symptoms are directly linked to autoantibodies targeting postsynaptic receptors of the neuromuscular junction. However, the underlying immunopathogenesis remains to be elucidated. This single-center study aimed to characterize peripheral blood lymphocytes in MG patients and to identify prognostic biomarkers. We retrospectively reanalyzed clinical flow cytometric data on blood B and T cells from 76 incident MG cases, comparing them to healthy individuals of relevant age range. Clinical data was collected from the Swedish MG registry and used for outcome analyses. Flow cytometry analyses were based on standardized panels established by the Human Immunology Projec

SUBMITTER: Lindahl H 

PROVIDER: S-EPMC12172393 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature