HHHFNC Versus NIPPV Delivered by Long Narrow Cannula in Preterm Infants: Randomized Noninferiority Trial.

ABSTRACT:

Background

Heated humidified high flow (HHHFNC) and nasal intermittent positive pressure ventilation (NIPPV) delivered by cannula with long and narrow tubing (CLNT) are increasingly used in preterm infants for providing noninvasive respiratory support, due to their high comfort level and minimal nasal trauma. Despite their widespread use, no randomized controlled trial has been conducted so far.

Objective

Determine whether HHHFNC is non-inferior to CLNT-NIPPV in providing respiratory support for preterm infants.

Study design

An unblinded, randomized controlled, non-inferiority multicenter trial.

Methodology

Preterm infants randomized to either HHHFNC or CLNT-NIPPV. Infants born > 28 weeks of gestation were eligible to enter the study either as primary treatment

SUBMITTER: Gover A 

PROVIDER: S-EPMC12172398 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature