Epidemiological, virological, and pathogenic insights into Nairobi sheep disease virus infection in sheep and goats in China.

ABSTRACT: Nairobi sheep disease virus (NSDV), a tick-borne pathogen in the Orthonairovirus genus of the Nairoviridae family, causes Nairobi sheep disease (NSD), which has mortality rates over 90% in sheep and goats. Historically, NSD outbreaks in East Africa and South Asia have led to considerable economic losses. Although NSDV genomic fragments have been detected in ticks in China, there has been a notable absence of reported infections in local sheep and goats. In this study, we report the first identification of NSDV infection in sheep and goats in China. Through meta-transcriptomics sequencing, NSDV was found in infected spleen tissue with high viral abundance. Epidemiological investigations indicated a 4.1% positive rate for NSDV RNA and a 29.9% seroprevalence rate, confirming the

SUBMITTER: Yao X-Y 

PROVIDER: S-EPMC12172417 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature