Genome-scale metabolic model of <i>Staphylococcus epidermidis</i> ATCC 12228 matches <i>in vitro</i> conditions.

ABSTRACT: Staphylococcus epidermidis, a commensal bacterium inhabiting collagen-rich areas like human skin, has gained significance due to its probiotic potential in the nasal microbiome and as a leading cause of nosocomial infections. While infrequently leading to severe illnesses, S. epidermidis exerts a significant influence, particularly in its close association with implant-related infections and its role as a classic opportunistic biofilm former. Understanding its opportunistic nature is crucial for developing novel therapeutic strategies, addressing both its beneficial and pathogenic aspects, and alleviating the burdens it imposes on patients and healthcare systems. Here, we employ genome-scale metabolic modeling as a powerful tool to elucidate the metabolic capabilities of S

SUBMITTER: Leonidou N 

PROVIDER: S-EPMC12172418 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature