A Very Readily Prepared Ligand for Rhodium Catalyzed Propene Hydroformylation.

ABSTRACT: In the search for an easy-to-make ligand that would enable Rh catalyzed hydroformylation of propene to favor the branched aldehydes, iso-butanal, bis-phosphonites and bis-phosphoramidites were designed. Catalysts derived from bis-phosphonites gave the desired low n:iso ratios, but were unstable to hydrolysis. A bis-phosphoramidite ligand (EasyDiPhos) that can be made in just one synthetic step has been discovered that enables Rh-catalyzed hydroformylations to proceed with unusually low n:iso ratios. They were also found to have significant stability to moisture, air, and to relatively high temperatures during hydroformylation conditions. The latter was studied using a combination of high pressure infra-red (HPIR) spectroscopy and NMR analysis of the catalyst resting state after 1 week unde

SUBMITTER: Fuentes JA 

PROVIDER: S-EPMC12172607 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature