Parkinsonian central pain is linked to the connectivity of the nucleus accumbens and the anterior insula.

ABSTRACT: Pain is a frequent and disabling non-motor symptom of Parkinson's Disease (PD). Yet, no treatment to date can efficiently reduce this pain. This article investigates the brain functional connectivity of PD patients with central pain and the effects of levodopa and oxycodone on this connectivity. Thirty-eight PD patients received either levodopa, oxycodone, or a placebo during an eight-week period. Pain intensity was evaluated using the Visual Analogue Scale and resting-state functional connectivity was measured before and after treatments. PD patients were also separated into two groups: responders and non-responders. At baseline, the intensity of pain was correlated with the connectivity between the anterior insula and the posterior cingulate cortex and between the nucleus accumbens, the

SUBMITTER: Joineau K 

PROVIDER: S-EPMC12172763 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature